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Article

Severe neurodegeneration in brains of transgenic rats producing human tau prions.

Acta neuropathologica - 20 Aug 2024

Ayers Jacob, Lopez T Peter, Steele Ian T, Oehler Abby, Roman-Albarran Rigo, Cleveland Elisa, Chong Alex, Carlson George A, Condello Carlo, Prusiner Stanley B

Abstract excerpt

Both wild-type and mutant tau proteins can misfold into prions and self-propagate in the central nervous system of animals and people. To extend the work of others, we investigated the molecular basis of tau prion-mediated neurodegeneration in transgenic (Tg) rats expressing mutant human tau (P301S); this line of Tg rats is denoted Tg12099. We used the rat Prnp promoter to drive the overexpression of mutant tau...

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Identifiers

PMID: 39160375
DOI: 10.1007/s00401-024-02771-5
PMCID: PMC11333523

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