Article
A study of genetic diversity in the gene encoding the circumsporozoite protein (CSP) of Plasmodium falciparum from different transmission areas--XVI. Asembo Bay Cohort Project.
Molecular and biochemical parasitology - 1 Jan 2002
Escalante Ananias A, Grebert Heather M, Isea Raul, Goldman Ira F, Basco Leonardo, Magris Magda, Biswas Sukla, Kariuki Simon, Lal Altaf A
Abstract excerpt
We have investigated the genetic diversity of the gene encoding the CS protein. A total of 75 complete and 96 partial sequences are studied. We find high levels of genetic polymorphisms as evidenced by 50 and 24 alleles at the Th2R and Th3R epitopes, respectively. Overall, we find that African isolates are more polymorphic as compared with parasites from other geographic regions. We conclude that the uneven...
Topics
- Alleles
- Animals
- Base Sequence
- Cohort Studies
- Epitopes, T-Lymphocyte
- Evolution, Molecular
- Gene Frequency
- Genes, Protozoan
- Geography
- Malaria, Falciparum
- Membrane Glycoproteins
- Molecular Sequence Data