Origins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of Plasmodium falciparum.

doi:10.1016/j.gene.2006.03.011

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Article

Origins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of Plasmodium falciparum.

Gene - 19 Jul 2006

Hoffmann Erika H E, Malafronte Rosely S, Moraes-Avila Sandra L, Osakabe Ana Lúcia, Wunderlich Gerhard, Durham Alan M, Ribolla Paulo Eduardo M, del Portillo Hernando A, Ferreira Marcelo U

Abstract excerpt

The recent evolution of Plasmodium falciparum is at odds with the extensive polymorphism found in most genes coding for antigens. Here, we examined the patterns and putative mechanisms of sequence diversification in the merozoite surface protein-2 (MSP-2), a major malarial repetitive surface anti...

Topics

Alleles
Animals
Antigens, Protozoan
Base Sequence
Brazil
Chromosome Mapping
Chromosomes
Computer Simulation
DNA, Protozoan
Evolution, Molecular
Gene Conversion
Genes, Insect
Genetic Markers
Haplotypes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Malaria Vaccines

Markov Chains

Microsatellite Repeats

Source

Open in PubMed

Identifiers

PMID: 16716539
DOI: 10.1016/j.gene.2006.03.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-16716539-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.