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Article

Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53.

Blood - 15 Mar 2007

Irish Jonathan M, Anensen Nina, Hovland Randi, Skavland Jørn, Børresen-Dale Anne-Lise, Bruserud Oystein, Nolan Garry P, Gjertsen Bjørn T

Abstract excerpt

Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses wild-type p53 activity in AML. We demonstrate that wild-type p53 protein is expressed in primary leukemic blasts from patients with de...

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Share to DNA Damage
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Protein Isoforms

Share to Proto-Oncogene Proteins c-bcl-2

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Source

Identifiers

PMID: 17105820
DOI: 10.1182/blood-2006-02-004234

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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