Article

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn <sup>2+</sup> -dependent amidases

2018-10-12

Abstract excerpt

<h4>ABSTRACT</h4> Human alkaline ceramidase 3 (ACER3) is one of three alkaline ceramidases (ACERs) that catalyze the conversion of ceramide to sphingosine. ACERs are the members of the CREST superfamily of integral-membrane lipid hydrolases, including the adiponectin receptors which play roles in energy metabolism. All CREST members conserve a set of three Histidine, one Aspartate, and one Serine residue. However...

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Literature Corpus work: aadc0bc9-25b1-5a9d-98cf-fe39986c6e0f
DOI: 10.1101/442202

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