Article
An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity.
The Journal of cell biology - 2 Jan 2017
Liu Li-Ka, Choudhary Vineet, Toulmay Alexandre, Prinz William A
Abstract excerpt
Ceramides are key intermediates in sphingolipid biosynthesis and potent signaling molecules. However, excess ceramide is toxic, causing growth arrest and apoptosis. In this study, we identify a novel mechanism by which cells prevent the toxic accumulation of ceramides; they facilitate nonvesicular ceramide transfer from the endoplasmic reticulum (ER) to the Golgi complex, where ceramides are converted to complex...
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