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Article

Structural basis for the activation of acid ceramidase.

Nature communications - 24 Apr 2018

Gebai Ahmad, Gorelik Alexei, Li Zixian, Illes Katalin, Nagar Bhushan

Abstract excerpt

Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes. Abnormal function of aCDase leads to Farber disease, spinal muscular atrophy with progressive myoclonic epilepsy, and is associated with Alzheimer's, diabetes, and cancer. Here, we present crystal structures of mammalian aCDases in both proenzyme and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

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Source

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Identifiers

PMID: 29692406
DOI: 10.1038/s41467-018-03844-2
PMCID: PMC5915598

Genes

ASAH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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