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Article

Lip1p: a novel subunit of acyl-CoA ceramide synthase.

The EMBO journal - 23 Feb 2005

Vallée Béatrice, Riezman Howard

Abstract excerpt

Ceramide plays a crucial role as a basic building block of sphingolipids, but also as a signalling molecule mediating the fate of the cell. Although Lac1p and Lag1p have been shown recently to be involved in acyl-CoA-dependent ceramide synthesis, ceramide synthase is still poorly characterized. In this study, we expressed tagged versions of Lac1p and Lag1p and purified them to near homogeneity. They copurified...

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PMID: 15692566
DOI: 10.1038/sj.emboj.7600562
PMCID: PMC549621

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