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Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

15 Mar 2017

Abstract excerpt

ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional regulatory mechanism of ACER2 gene and its potential role in the regulation of autophagy remain unknown. In this study, we have for the first time identified the human ACER2 gene promoter, and found that human ACER2 transcription is...

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PMID: 28294157
DOI: 10.1038/srep44573

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