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Article

Spontaneous mutation frequency is elevated in skin of harlequin (hq)/Big Blue mice.

Mutagenesis - 1 May 2010

Van Osch F Skylar, Piliguian Mark, Hill Kathleen A

Abstract excerpt

The harlequin (hq)/Big Blue mouse is a novel model of premature ageing distinguished by a patchy coat, early-onset neurodegeneration, stress-induced heart disease and a mutation detection assay applicable to individual tissues. The hq mutation causes down-regulation of apoptosis-inducing factor a...

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PMID: 20089602
DOI: 10.1093/mutage/gep069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20089602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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