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Article

Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2021

Hintze Maik, Griesing Sebastian, Michels Marion, Blanck Birgit, Wischhof Lena, Hartmann Dieter, Bano Daniele, Franz Thomas

Abstract excerpt

We investigated the contribution of apoptosis-inducing factor (AIF), a key regulator of mitochondrial biogenesis, in supporting hair growth. We report that pelage abnormalities developed during hair follicle (HF) morphogenesis in Harlequin (Hq) mutant mice. Fragility of the hair cortex was associated with decreased expression of genes encoding structural hair proteins, though key transcriptional regulators of HF...

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Identifiers

PMID: 33367954
DOI: 10.1007/s00335-020-09854-0
PMCID: PMC7878237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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