Article
Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration.
Experimental eye research - 1 Dec 2011
Laliberté Alex M, MacPherson Thomas C, Micks Taft, Yan Alex, Hill Kathleen A
Abstract excerpt
Current animal models of retinal disease often involve the rapid development of a retinal disease phenotype; however, this is at odds with age-related diseases that take many years to manifest clinical symptoms. The present study was performed to examine an apoptosis-inducing factor (Aif)-deficient model, the harlequin carrier mouse (X(hq)X), and determine how mitochondrial dysfunction and subsequent accelerated...
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