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Article

Mutation frequency is not elevated in the cerebellum of harlequin/Big Blue(®) mice but Class II deletions occur preferentially in young harlequin cerebellum.

Mutation research - 10 Feb 2011

Prtenjaca Anita, Hill Kathleen A

Abstract excerpt

The harlequin (hq)/Big Blue(®) mouse is a model of premature aging with neurodegeneration and a transgenic mutation target (λcII gene) for in vivo mutation analysis in individual tissues. The hq mutation results in downregulation of the apoptosis-inducing factor (Aif) gene with conflicting reports of elevated oxidative stress in neurons. Previously, the cerebellum of hq disease mice was reported to have a...

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Identifiers

PMID: 21195094
DOI: 10.1016/j.mrfmmm.2010.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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