Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice.

PloS one - 1 Jan 2011

Schiff Manuel, Bénit Paule, El-Khoury Riyad, Schlemmer Dimitri, Benoist Jean-François, Rustin Pierre

Abstract excerpt

BACKGROUND: Therapeutic options in human mitochondrial oxidative phosphorylation (OXPHOS) diseases have been poorly evaluated mostly because of the scarcity of cohorts and the inter-individual variability of disease progression. Thus, while a high fat diet (HFD) is often recommended, data regarding efficacy are limited. Our objectives were 1) to determine our ability to evaluate therapeutic options in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carnitine
Share to Cell Respiration
Share to Cytoprotection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex I

Share to Palmitates

Share to Rotarod Performance Test

Share to Serum Albumin, Bovine

Share to Succinic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 22174907
DOI: 10.1371/journal.pone.0028823
PMCID: PMC3236768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice.PMID 22174907Read ↗

The variability of the harlequin mouse phenotype resembles that of human mitochondrial-complex I-deficiency syndromes.Semantic proximity Read ↗

A disease-associated Aifm1 variant induces severe myopathy in knockin mice.Semantic proximity Read ↗

Ketogenic diet slows down mitochondrial myopathy progression in mice.Semantic proximity Read ↗

Longitudinal study of Pex1-G844D NMRI mouse model: A robust pre-clinical model for mild Zellweger spectrum disorder.Semantic proximity Read ↗

Genetic background influences mitochondrial function: modeling mitochondrial disease for therapeutic development.Semantic proximity Read ↗

Spontaneous mutation frequency is elevated in skin of harlequin (hq)/Big Blue mice.Semantic proximity Read ↗

Apoptosis-Inducing Factor Deficiency Induces Early Mitochondrial Degeneration in Brain Followed by Progressive Multifocal NeuropathologySemantic proximity Read ↗

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition.Semantic proximity Read ↗

Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice.Semantic proximity Read ↗

A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.Semantic proximity Read ↗

Empirical versus theoretical power and type I error (false-positive) rates estimated from real murine aging research data.Semantic proximity Read ↗

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.