Article
Increased mutation in mice genetically predisposed to oxidative damage in the brain.
Mutation research - 22 Nov 2004
Stringer James R, Larson Jon S, Fischer Jared M, Stringer Saundra L
Abstract excerpt
Harlequin (Hq) mice develop ataxia due to an X-linked recessive mutation in the gene encoding apoptosis-inducing factor (Aif). Brain cells in Hq mice contain the modified base 8-hydroxydeoxyguanosine (8-OHdG), suggesting that the defect in Aif causes increased DNA oxidation in these cells. Because oxidative damage is mutagenic, Hq mice might suffer increased mutation in the brain. To examine this possibility,...
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