Construction of aromatic dependent Shigella flexneri 2a live vaccine candidate strains: deletion mutations in the aroA and the aroD genes.

doi:10.1016/0264-410x(91)90308-s

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Article

Construction of aromatic dependent Shigella flexneri 2a live vaccine candidate strains: deletion mutations in the aroA and the aroD genes.

Vaccine - 1 Jan 1991

Verma N K, Lindberg A A

Abstract excerpt

Live Shigella flexneri 2a vaccine candidate strains with deletion mutations in the aro genes were constructed. Tn10-generated auxotrophic mutations were transduced from Escherichia coli to S. flexneri 2a with bacteriophage P1CmCts. The tetracycline-sensitive derivatives of Tn10 mutants obtained w...

Topics

Animals
Bacterial Vaccines
Chromosome Deletion
Dysentery, Bacillary
Female
Guinea Pigs
Immunization
Mutation
Shigella flexneri

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