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Article

Construction of aromatic dependent Shigella flexneri 2a live vaccine candidate strains: deletion mutations in the aroA and the aroD genes.

Vaccine - 1 Jan 1991

Verma N K, Lindberg A A

Abstract excerpt

Live Shigella flexneri 2a vaccine candidate strains with deletion mutations in the aro genes were constructed. Tn10-generated auxotrophic mutations were transduced from Escherichia coli to S. flexneri 2a with bacteriophage P1CmCts. The tetracycline-sensitive derivatives of Tn10 mutants obtained were selected on Bochner's medium and checked by DNA-DNA hybridization using aroA and aroD gene specific probes. The...

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PMID: 2008803
DOI: 10.1016/0264-410x(91)90308-s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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