Article
Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen.
Vaccine - 1 Jan 1992
Newland J W, Hale T L, Formal S B
Abstract excerpt
The construction and characterization of EcSf2a-2, an aroD-deleted Escherichia coli-Shigella hybrid vaccine carrying chromosomal and plasmid genes from Shigella flexneri and expressing S. flexneri 2a somatic antigen in association with E. coli K12 core are described. Expression of hybrid lipopoly...
Topics
- Animals
- Antibodies, Bacterial
- Antigens, Bacterial
- Escherichia coli
- Gene Deletion
- Genotype
- Humans
- Immunoglobulin M
- Macaca mulatta
- Phenotype
- Plasmids
- Rabbits
- Shigella flexneri
- Species Specificity
- Vaccines, Attenuated
- Vaccines, Synthetic