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Article

Analysis of virulence and inflammatory potential of Shigella flexneri purine biosynthesis mutants.

Infection and immunity - 1 Dec 2003

Cersini Antonella, Martino Maria Celeste, Martini Irene, Rossi Giacomo, Bernardini Maria Lina

Abstract excerpt

Several Shigella flexneri mutants with defects in aromatic amino acid and/or purine biosynthesis have been evaluated as vaccines in humans or in animal models. To be suitable as a vaccine, a mutant has to show virulence attenuation, minimal reactogenicity, and a good immunogenic potential in animal models. With this aim, we have constructed five S. flexneri 5 (wild-type strain M90T) mutants with inactivation of...

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Identifiers

PMID: 14638790
DOI: 10.1128/IAI.71.12.7002-7013.2003
PMCID: PMC308888

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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