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Article

Plasma gangliosides correlate with disease stages and symptom severity in Huntington’s disease carriers

2025-03-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Gangliosides - glycosphingolipids that modulate cell signaling and neuronal functions - are decreased in Huntington’s disease (HD) models and patients’ brains. Restoring ganglioside GM1 has therapeutic benefits in HD mice, slowing neurodegeneration and improving symptoms. This suggests gangliosides might contribute to HD pathogenesis. However, their link to disease severity...

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Literature Corpus work
916d1c05-1650-5333-83c5-13e229ca406d
DOI
10.1101/2025.03.21.25324430
Open publication

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Plasma gangliosides correlate with disease stages and symptom severity in Huntington’s disease carriersDOI 10.1101/2025.03.21.25324430
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