Article
EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas.
PloS one - 1 Jan 2011
Ryan Russell J H, Nitta Mai, Borger Darrell, Zukerberg Lawrence R, Ferry Judith A, Harris Nancy Lee, Iafrate A John, Bernstein Bradley E, Sohani Aliyah R, Le Long Phi
Abstract excerpt
Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification. As an initial step toward screening patients for cancer genotype-directed therapy, we developed a screening assay for EZH2 codon 641 mutations amenable for testing...
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