Article
The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications.
Infection and immunity - 1 Dec 2015
Olsen Randall J, Raghuram Anjali, Cantu Concepcion, Hartman Meredith H, Jimenez Francisco E, Lee Susan, Ngo Ashley, Rice Kelsey A, Saddington Deborah, Spillman Hannaka, Valson Chandni, Flores Anthony R, Beres Stephen B, Long S Wesley, Nasser Waleed, Musser James M
Abstract excerpt
Group A streptococcus (GAS), the causative agent of pharyngitis and necrotizing fasciitis, secretes the potent cysteine protease SpeB. Several lines of evidence suggest that SpeB is an important virulence factor. SpeB is expressed in human infections, protects mice from lethal challenge when used as a vaccine, and contributes significantly to tissue destruction and dissemination in animal models. However, recent...
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