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Article

Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Dec 2009

Park Sang Wook, Chung Nak Gyun, Hur Soo Young, Kim Ho Shik, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

Hypoxia is a general feature of solid cancer tissues. Hypoxia upregulates hypoxia-inducible factor 1alpha (HIF1alpha) that transactivates downstream genes and contributes to cancer pathogenesis. HIF1alpha is upregulated not only by hypoxia but also by genetic alterations in HIF1alpha-related gene...

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Source

Identifiers

PMID: 20078552
DOI: 10.1111/j.1600-0463.2009.02550.x

Genes

CUL2
VHL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20078552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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