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Article

Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk.

Molecular carcinogenesis - 1 Sept 2010

Knechtel Gudrun, Szkandera Joanna, Stotz Michael, Hofmann Günter, Langsenlehner Uwe, Krippl Peter, Samonigg Hellmut, Renner Wilfried, Langner Cord, Dehchamani Dadbeh, Gerger Armin

Abstract excerpt

With an incidence of about 300 000 new cases colorectal cancer (CRC) is the second leading cause of cancer-related death in Europe and the United States. Environmental and genetic factors influence CRC risk. Hypoxia-inducible factor-1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1 alpha and HIF-1 beta, plays a critical role in oxygen homeostasis and is involved in angiogenesis and cell...

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PMID: 20572162
DOI: 10.1002/mc.20655

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MVD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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