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Article

Modulation of CDK2-AP1 (p12(DOC-1)) expression in human colorectal cancer.

Oncogene - 19 May 2005

Yuan Ziquan, Gaba Anu G, Kent Tara Sotsky, Bennett Anna, Miller Agnes, Weber Thomas K

Abstract excerpt

We have previously demonstrated an association between microsatellite instability and decreased CDK2-AP1 (p12(DOC-1)) expression in human colorectal cancer (CRC) cell lines. In those same studies, induction of CDK2-AP1 expression promoted both cell cycle arrest and apoptosis. The goals of our present study were to better understand the mechanisms leading to reduced CDK2-AP1 expression in microsatellite unstable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15806176
DOI: 10.1038/sj.onc.1208378

Genes

CDK2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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