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Article

Prevalence and prognosis of hypoxia-inducible factor-2α (HIF-2α) pathway gene mutations across advanced solid tumors.

Cancer medicine - 1 Jun 2024

Zhong Wenjun, Ma Jiemin, Chen Cai, Dettman E J, Cristescu Razvan, Naik Girish S, Jin Fan, Shao Changxia

Abstract excerpt

INTRODUCTION: Hypoxia-inducible factor-2α (HIF-2α) modulates the hypoxic response pathway in tumors; however, mutations in pathways (including SDHA, SDHB, SDHC, SDHD, FH, and VHL genes) that are suspected to activate HIF-2α are poorly understood, with limited understanding of the prevalence and clinical prognosis. METHODS: This retrospective observational study used a de-identified nationwide (US-based)...

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Identifiers

PMID: 38864477
DOI: 10.1002/cam4.7358
PMCID: PMC11167604

Genes

VHL
SDHD
FH
SDHA
SDHB
SDHC

Provenance

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