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Article

Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.

Cancer research - 1 May 2012

Xue Xiang, Taylor Matthew, Anderson Erik, Hao Cathy, Qu Aijuan, Greenson Joel K, Zimmermann Ellen M, Gonzalez Frank J, Shah Yatrik M

Abstract excerpt

Hypoxia-inducible factor (HIF), a key modulator of the transcriptional response to hypoxia, is increased in colon cancer. However, the role of HIF in colon carcinogenesis in vivo remains unclear. In this study, we found that intestinal epithelium-specific disruption of the von Hippel-Lindau tumor suppressor protein (VHL) resulted in constitutive HIF signaling, and increased HIF expression augmented colon...

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Source

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Identifiers

PMID: 22419665
DOI: 10.1158/0008-5472.CAN-11-3836
PMCID: PMC3342485

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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