Article
Polymorphisms in the tropomyosin TPM1 short isoform promoter alter gene expression and are associated with increased risk of metabolic syndrome.
American journal of hypertension - 1 Apr 2010
Savill Stuart A, Leitch Helen F, Daly Ann K, Harvey John N, Thomas Trevor H
Abstract excerpt
BACKGROUND: Inflammation contributes to the development of atherosclerotic lesions in the metabolic syndrome. Tropomyosin isoform expression is altered in this disease and has a role in inflammatory cell plasticity, motility, and insulin sensitivity. We determined the frequency of haplotype carriage of three single-nucleotide polymorphisms (SNPs) in the short isoform promoter of the TPM1 gene in 300 normal...
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