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Article

Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene.

Human mutation - 1 Jan 2008

Rubin Diana, Schneider-Muntau Alexandra, Klapper Maja, Nitz Inke, Helwig Ulf, Fölsch Ulrich R, Schrezenmeir Jürgen, Döring Frank

Abstract excerpt

The microsomal triglyceride transfer protein (MTTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from the intestine and liver. According to this function, polymorphic sites in the MTTP gene showed associations to low-density lipoprotein (LDL) cholesterol and related traits of the metabolic syndrome. Here we studied the functional impact of common MTTP promoter...

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Identifiers

PMID: 17854051
DOI: 10.1002/humu.20615

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MTTP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene.PMID 17854051Read ↗

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A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels.Semantic proximity Read ↗

Postprandial plasma ApoB-48 levels are influenced by a polymorphism in the promoter of the microsomal triglyceride transfer protein gene.Semantic proximity Read ↗

A functional polymorphism in the promoter region of the microsomal triglyceride transfer protein (MTP -493G/T) influences lipoprotein phenotype in familial hypercholesterolemia.Semantic proximity Read ↗

Microsomal triglyceride transfer protein gene polymorphism strongly influences circulating malondialdehyde-modified low-density lipoprotein.Semantic proximity Read ↗

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