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Article

Functional and structural profiling of the human thrombopoietin gene promoter.

The Journal of biological chemistry - 5 Sept 2008

Dördelmann Corinna, Telgmann Ralph, Brand Eva, Hagedorn Claudia, Schröer Bianca, Hasenkamp Sandra, Baumgart Peter, Kleine-Katthöfer Peter, Paul Martin, Brand-Herrmann Stefan-Martin

Abstract excerpt

Human thrombopoietin (TPO) is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. The THPO promoter structure is still controversial. By reverse transcription-PCR, we confirm that THPO transcription is cell line-dependently initiated at two alternative promoters, which we newly designated P1a and P1. We subsequently electrophoretically scanned...

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Share to Cardiovascular Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Megakaryocytes

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 18617523
DOI: 10.1074/jbc.M802198200
PMCID: PMC3259845

Genes

THPO
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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