Article
Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits.
Human mutation - 1 Apr 2007
Abdollahi Mohammad R, Lewis Rohan M, Gaunt Tom R, Cumming Debbie V E, Rodriguez Santiago, Rose-Zerilli Matthew, Collins Andrew R, Syddall Holly E, Howell William M, Cooper Cyrus, Godfrey Keith M, Cameron Iain T, Day Ian N M
Abstract excerpt
The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been reported to associate with hypertension, myocardial infarction (MI), and metabolic traits. Here we describe a novel approach to quantitation of transcript haplotypes (QTH) of AGTR1. To determine relative allelic...
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