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Article

Haplodeficiency of activin receptor-like kinase 4 alleviates myocardial infarction-induced cardiac fibrosis and preserves cardiac function.

Journal of molecular and cellular cardiology - 1 Apr 2017

Chen Yi-He, Wang Qian, Li Chang-Yi, Hou Jian-Wen, Chen Xiao-Meng, Zhou Qing, Chen Jie, Wang Yue-Peng, Li Yi-Gang

Abstract excerpt

Cardiac fibrosis (CF), a repairing process following myocardial infarction (MI), is characterized by abnormal proliferation of cardiac fibroblasts and excessive deposition of extracellular matrix (ECM) resulting in inevitable resultant heart failure. TGF-β (transforming growth factor-β)/ALK5 (Activin receptor-like kinase 5)/Smad2/3/4 pathways have been reported to be involved in the process. Recent studies have...

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Identifiers

PMID: 28214509
DOI: 10.1016/j.yjmcc.2017.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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