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Article

Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila

18 Dec 2014

Abstract excerpt

Abnormally phosphorylated Tau protein, the major component of neurofibrillary tangles, is critical in the pathogenesis of Alzheimer's disease and related Tauopathies. We used Drosophila to examine the role of key disease-associated phosphorylation sites on Tau-mediated neurotoxicity. We present evidence that the late-appearing phosphorylation on Ser(238) rather than hyperphosphorylation per se is essential for...

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PMID: 25524708
DOI: 10.1093/hmg/ddu726

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