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Article

Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma

1 Jan 2014

Abstract excerpt

Despite the importance of Hedgehog signaling in bone development, the relationship between Hedgehog pathway expression and osteosarcoma clinical characteristics and outcome has not been investigated. In this study of 43 high-grade human osteosarcoma samples, we detected high expression levels of the Hedgehog ligand gene, IHH, and target genes, PTCH1 and GLI1, in most samples. Further analysis in tumors of...

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PMID: 24799831
DOI: 10.1155/2014/261804

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