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Article

Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection

1 Jan 2010

Abstract excerpt

AIM: To evaluate the suitability of rupintrivir against Enterovirus 71 (EV71) induced severe clinical symptoms using computational methods. METHODS: The structure of EV71 3C protease was predicted by homology modeling. The binding free energies between rupintrivir and EV71 3C and human rhinovirus 3C protease were computed by molecular dynamics and molecular mechanics Poisson-Boltzmann/surface area and molecular...

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PMID: 20066739
DOI: 10.3748/wjg.v16.i2.201

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