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Article

Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71).

International journal of molecular sciences - 15 Aug 2021

Lalani Salima, Masomian Malihe, Poh Chit Laa

Abstract excerpt

Enterovirus A71 (EV-A71) is a major neurovirulent agent capable of causing severe hand, foot and mouth disease (HFMD) associated with neurological complications and death. Currently, no FDA-approved antiviral is available for the treatment of EV-A71 infections. The flavonoid silymarin was shown to exert virucidal effects, but the binding site on the capsid was unknown. In this study, the ligand interacting site...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34445463
DOI: 10.3390/ijms22168757
PMCID: PMC8395941

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Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71).PMID 34445463Read ↗

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Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting moleculesSemantic proximity Read ↗

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry.Semantic proximity Read ↗

Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A.Semantic proximity Read ↗

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