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Article

Quantitative variation in plasma angiotensin-I converting enzyme activity shows allelic heterogeneity in the ABO blood group locus.

Annals of human genetics - 1 Nov 2013

Terao Chikashi, Bayoumi Nervana, McKenzie Colin A, Zelenika Diana, Muro Shigeo, Mishima Michiaki, Connell John M C, Vickers Mark A, Lathrop G Mark, Farrall Martin, Matsuda Fumihiko, Keavney Bernard D

Abstract excerpt

Angiotensin-I converting enzyme (ACE) occupies a pivotal role in cardiovascular homeostasis. Major loci for plasma ACE have been identified at ACE on Chromosome 17 and at ABO on Chromosome 9. We sought to characterise the genetic architecture of plasma ACE at finer resolution in two populations. We carried out a GWAS in 1810 individuals of Japanese ethnicity; this identified signals at ACE and ABO that together...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23937567
DOI: 10.1111/ahg.12034

Genes

ACE
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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