Article
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
Nature genetics - 1 Dec 2010
Sotoodehnia Nona, Isaacs Aaron, de Bakker Paul I W, Dörr Marcus, Newton-Cheh Christopher, Nolte Ilja M, van der Harst Pim, Müller Martina, Eijgelsheim Mark, Alonso Alvaro, Hicks Andrew A, Padmanabhan Sandosh, Hayward Caroline, Smith Albert Vernon, Polasek Ozren, Giovannone Steven, Fu Jingyuan, Magnani Jared W, Marciante Kristin D, Pfeufer Arne, Gharib Sina A, Teumer Alexander, Li Man, Bis Joshua C, Rivadeneira Fernando, Aspelund Thor, Köttgen Anna, Johnson Toby, Rice Kenneth, Sie Mark P S, Wang Ying A, Klopp Norman, Fuchsberger Christian, Wild Sarah H, Mateo Leach Irene, Estrada Karol, Völker Uwe, Wright Alan F, Asselbergs Folkert W, Qu Jiaxiang, Chakravarti Aravinda, Sinner Moritz F, Kors Jan A, Petersmann Astrid, Harris Tamara B, Soliman Elsayed Z, Munroe Patricia B, Psaty Bruce M, Oostra Ben A, Cupples L Adrienne, Perz Siegfried, de Boer Rudolf A, Uitterlinden André G, Völzke Henry, Spector Timothy D, Liu Fang-Yu, Boerwinkle Eric, Dominiczak Anna F, Rotter Jerome I, van Herpen Gé, Levy Daniel, Wichmann H-Erich, van Gilst Wiek H, Witteman Jacqueline C M, Kroemer Heyo K, Kao W H Linda, Heckbert Susan R, Meitinger Thomas, Hofman Albert, Campbell Harry, Folsom Aaron R, van Veldhuisen Dirk J, Schwienbacher Christine, O'Donnell Christopher J, Volpato Claudia Beu, Caulfield Mark J, Connell John M, Launer Lenore, Lu Xiaowen, Franke Lude, Fehrmann Rudolf S N, te Meerman Gerard, Groen Harry J M, Weersma Rinse K, van den Berg Leonard H, Wijmenga Cisca, Ophoff Roel A, Navis Gerjan, Rudan Igor, Snieder Harold, Wilson James F, Pramstaller Peter P, Siscovick David S, Wang Thomas J, Gudnason Vilmundur, van Duijn Cornelia M, Felix Stephan B, Fishman Glenn I, Jamshidi Yalda, Stricker Bruno H Ch, Samani Nilesh J, Kääb Stefan, Arking Dan E
Abstract excerpt
The QRS interval, from the beginning of the Q wave to the end of the S wave on an electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for mortality, sudden death and heart failure. We performed a genome-wide association meta-analysis in 40,407 individuals of European descent from 14 studies, with further genotyping in 7,170 additional Europeans, and we identified 22...
