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Article

Several common variants modulate heart rate, PR interval and QRS duration.

Nature genetics - 1 Feb 2010

Holm Hilma, Gudbjartsson Daniel F, Arnar David O, Thorleifsson Gudmar, Thorgeirsson Gudmundur, Stefansdottir Hrafnhildur, Gudjonsson Sigurjon A, Jonasdottir Aslaug, Mathiesen Ellisiv B, Njølstad Inger, Nyrnes Audhild, Wilsgaard Tom, Hald Erin M, Hveem Kristian, Stoltenberg Camilla, Løchen Maja-Lisa, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari

Abstract excerpt

Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20062063
DOI: 10.1038/ng.511

Genes

TBX5
CAV1
ARHGAP24
MYH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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