Article
Genome-wide association study of PR interval.
Nature genetics - 1 Feb 2010
Pfeufer Arne, van Noord Charlotte, Marciante Kristin D, Arking Dan E, Larson Martin G, Smith Albert Vernon, Tarasov Kirill V, Müller Martina, Sotoodehnia Nona, Sinner Moritz F, Verwoert Germaine C, Li Man, Kao W H Linda, Köttgen Anna, Coresh Josef, Bis Joshua C, Psaty Bruce M, Rice Kenneth, Rotter Jerome I, Rivadeneira Fernando, Hofman Albert, Kors Jan A, Stricker Bruno H C, Uitterlinden André G, van Duijn Cornelia M, Beckmann Britt M, Sauter Wiebke, Gieger Christian, Lubitz Steven A, Newton-Cheh Christopher, Wang Thomas J, Magnani Jared W, Schnabel Renate B, Chung Mina K, Barnard John, Smith Jonathan D, Van Wagoner David R, Vasan Ramachandran S, Aspelund Thor, Eiriksdottir Gudny, Harris Tamara B, Launer Lenore J, Najjar Samer S, Lakatta Edward, Schlessinger David, Uda Manuela, Abecasis Gonçalo R, Müller-Myhsok Bertram, Ehret Georg B, Boerwinkle Eric, Chakravarti Aravinda, Soliman Elsayed Z, Lunetta Kathryn L, Perz Siegfried, Wichmann H-Erich, Meitinger Thomas, Levy Daniel, Gudnason Vilmundur, Ellinor Patrick T, Sanna Serena, Kääb Stefan, Witteman Jacqueline C M, Alonso Alvaro, Benjamin Emelia J, Heckbert Susan R
Abstract excerpt
The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci...
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