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Article

Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia

9 Jan 2010

Abstract excerpt

Intrinsic apoptosis defects underlie to a large extent the extended survival of malignant B cells in chronic lymphocytic leukemia (CLL). Here, we show that the Shc family adapter p66Shc uncouples the B-cell receptor (BCR) from the Erk- and Akt-dependent survival pathways, thereby enhancing B-cell apoptosis. p66Shc expression was found to be profoundly impaired in CLL B cells compared with normal peripheral B...

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PMID: 20061561
DOI: 10.1182/blood-2009-08-239244

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