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Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease

16 Aug 2008

Abstract excerpt

Resistance toward apoptotic stimuli mediated by overexpression of antiapoptotic factors or extracellular survival signals is considered to be responsible for accumulation of malignant B cells in chronic lymphocytic leukemia (CLL). TOSO was identified as overexpressed candidate gene in CLL, applying unit-transformation assays of publicly available microarray datasets. Based on CLL samples from 106 patients, TOSO...

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PMID: 18708628
DOI: 10.1182/blood-2008-05-157255

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