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Article

The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease

1 Jul 2009

Abstract excerpt

Deletion or mutation of the SAP gene is associated with the X-linked lymphoproliferative disease (XLP) that is characterized by extreme sensitivity to Epstein-Barr virus (EBV). Primary infection of the affected individuals leads to serious, sometimes fatal infectious mononucleosis (IM) and proneness to lymphoma. Our present results revealed a proapoptotic function of SAP by which it contributes to the maintenance...

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PMID: 19570996
DOI: 10.1073/pnas.0905691106

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The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative diseasePMID 19570996Read ↗

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Impaired Epstein-Barr virus–specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family–positive B-cell targetsSemantic proximity Read ↗

Mice deficient in the X‐linked lymphoproliferative disease gene <i>sap</i> exhibit increased susceptibility to murine gammaherpesvirus‐68 and hypo‐gammaglobulinemiaSemantic proximity Read ↗

Activation-dependent T cell expression of the X-linked lymphoproliferative disease gene product SLAM-associated protein and its assessment for patient detection.Semantic proximity Read ↗

SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.Semantic proximity Read ↗

Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome.Semantic proximity Read ↗

Wild-type p53 activates SAP expression in lymphoid cells.Semantic proximity Read ↗

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.Semantic proximity Read ↗

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