Article

LOX-1 and MMP-9 inhibition attenuates the detrimental effects of delayed rt-PA therapy and improves outcomes after acute ischemic stroke

2023-08-15

Abstract excerpt

<h4>Background</h4> Acute ischemic stroke triggers endothelial activation that disrupts vascular integrity and increases hemorrhagic transformation leading to worsened stroke outcomes. Recombinant-tissue plasminogen activator (rt-PA) is an effective treatment; however, its use is limited due to a restricted time window and high risk for hemorrhagic transformation, which in part may involve activation of metallopr...

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Literature Corpus work: 098c164c-f9cd-53a3-9608-8a2f1ed1a359
DOI: 10.1101/2023.08.08.552551

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