Article
Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.
Stroke - 1 Sept 2005
Tsuji Kiyoshi, Aoki Toshiaki, Tejima Emiri, Arai Ken, Lee Sun-Ryung, Atochin Dmitriy N, Huang Paul L, Wang Xiaoying, Montaner Joan, Lo Eng H
Abstract excerpt
BACKGROUND AND PURPOSE: Thrombolytic therapy with tissue plasminogen activator (tPA) in ischemic stroke is limited by increased risks of cerebral hemorrhage and brain injury. In part, these phenomena may be related to neurovascular proteolysis mediated by matrix metalloproteinases (MMPs). Here, we used a combination of pharmacological and genetic approaches to show that tPA promotes MMP-9 levels in stroke in...
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