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Article

Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2003

Siao Chia-Jen, Fernandez Susana R, Tsirka Stella E

Abstract excerpt

Tissue plasminogen activator (tPA) plays important roles in the brain after excitotoxic injury. It is released by both neurons and microglia and mediates neuronal death and microglial activation. Mice lacking tPA are resistant to excitotoxicity and show very limited microglial activation. Activated microglia are neurotoxic in culture, but this phenomenon is not well documented in vivo. To further understand the...

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PMID: 12716930
PMCID: PMC6742309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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