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Article

Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2010

Lilly Brenda, Clark Kathleen A, Yoshigi Masaaki, Pronovost Stephen, Wu Meng-Ling, Periasamy Muthu, Chi Mei, Paul Richard J, Yet Shaw-Fang, Beckerle Mary C

Abstract excerpt

OBJECTIVE: Cysteine-rich protein (CRP) 1 and 2 are cytoskeletal lin-11 isl-1 mec-3 (LIM)-domain proteins thought to be critical for smooth muscle differentiation. Loss of murine CRP2 does not overtly affect smooth muscle differentiation or vascular function but does exacerbate neointima formation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20056913
DOI: 10.1161/ATVBAHA.109.200741
PMCID: PMC2998921

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20056913-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.PMID 20056913Read ↗

Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells.Semantic proximity Read ↗

Intronic CArG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature.Semantic proximity Read ↗

Modulation of cysteine-rich protein 2 expression in vascular injury and atherosclerosis.Semantic proximity Read ↗

Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.Semantic proximity Read ↗

Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression.Semantic proximity Read ↗

Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.Semantic proximity Read ↗

Embryonic Expression Suggests an Important Role for CRP2/SmLIM in the Developing Cardiovascular SystemSemantic proximity Read ↗

Restricted inactivation of serum response factor to the cardiovascular system.Semantic proximity Read ↗

Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality.Semantic proximity Read ↗

Mural cell SRF controls pericyte migration, vessel patterning and blood flowSemantic proximity Read ↗

Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation.Semantic proximity Read ↗

The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.Semantic proximity Read ↗

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