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Article

Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation.

Circulation research - 30 Mar 2007

LeClair Renée J, Durmus Tahir, Wang Qiaozeng, Pyagay Peter, Terzic Aleksandra, Lindner Volkhard

Abstract excerpt

We identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found that it functionally increases cell migration while reducing collagen deposition. To address the in vivo role of Cthrc1, we generated transgenic...

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Identifiers

PMID: 17322174
DOI: 10.1161/01.RES.0000260806.99307.72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17322174-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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