Article
Modulation of cysteine-rich protein 2 expression in vascular injury and atherosclerosis.
Molecular biology reports - 1 Nov 2014
Chen Chung-Huang, Ho Hua-Hui, Wu Meng-Ling, Layne Matthew D, Yet Shaw-Fang
Abstract excerpt
Vascular smooth muscle cells (VSMCs) of the arterial wall normally display a differentiated and contractile phenotype. In response to arterial injury, VSMCs switch to a synthetic phenotype, contributing to vascular remodeling. Cysteine-rich protein 2 (CRP2) is a cytoskeletal protein expressed in VSMCs and blunts VSMC migration in part by sequestering the scaffolding protein p130Cas at focal adhesions. CRP2...
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