Article
Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.
The Journal of biological chemistry - 30 May 2008
Lin Da-Wei, Chang Il-Chi, Tseng Alan, Wu Meng-Ling, Chen Chung-Huang, Patenaude Cassandra A, Layne Matthew D, Yet Shaw-Fang
Abstract excerpt
CRP2 (cysteine-rich protein) is a vascular smooth muscle cell (VSMC)-expressed LIM-only protein. CRP2 associates with the actin cytoskeleton and interacts with transcription factors in the nucleus to mediate smooth muscle cell gene expression. Using Csrp2 (gene symbol of the mouse CRP2 gene)-deficient mice, we previously demonstrated that an absence of CRP2 enhances VSMC migration and increases neointima...
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