Article
A composite of multiple signals distinguishes causal variants in regions of positive selection.
Science (New York, N.Y.) - 12 Feb 2010
Grossman Sharon R, Shlyakhter Ilya, Shylakhter Ilya, Karlsson Elinor K, Byrne Elizabeth H, Morales Shannon, Frieden Gabriel, Hostetter Elizabeth, Angelino Elaine, Garber Manuel, Zuk Or, Lander Eric S, Schaffner Stephen F, Sabeti Pardis C
Abstract excerpt
The human genome contains hundreds of regions whose patterns of genetic variation indicate recent positive natural selection, yet for most the underlying gene and the advantageous mutation remain unknown. We developed a method, composite of multiple signals (CMS), that combines tests for multiple...
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